hrp0094fc7.6 | Fetal Endocrinology and Multisystem Disorders | ESPE2021

Reassessment of 18F-DOPA PET cut-offs in congenital hyperinsulinism

Gubaeva Diliara , Ryzhkova Daria , Nikitina Irina , Mitrofanova Lubov , Tiulpakov Anatoly , Melikyan Maria ,

Introduction: Congenital hyperinsulinism (CHI) is a rare but severe condition causing persistent hypoglycaemia. Approximately 30-40% of patients require surgical treatment. Extent of surgery depends on the histological form of the disease: subtotal pancreatectomy is done in diffuse CHI, whereas pancreatic resection is recommended in focal CHI.18F-DOPA PET scan is a gold-standard imaging technique that helps in differential diagnosis of diffuse and f...

hrp0095p1-237 | Diabetes and Insulin | ESPE2022

Neurodevelopmental outcomes in children with congenital hyperinsulinism.

Nikitina Irina , Sarakaeva Leyla , Eftich Egine , Bairov Vladimir , Sukhotskaya Anna , Smorodin Andrey , Ryzhkova Darya , Mitrofanova Lubov , Kelmanson Igor

Background: Congenital hyperinsulinism (CHI) is a rare group of genetic disorders resulting in persistent hypoglycemia which can lead to a considerable risk of neurological damage and developmental delay.Aim: To assess the neurodevelopmental outcome in children with CHI.Methods: Thirty-three patients with СHI aged from 7 to 58 months were included. All subjects underwent clinic...